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KMID : 0361620070420040444
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Journal of the Korean Orthopaedic Association
2007 Volume.42 No. 4 p.444 ~ p.452
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The Impact of Combined Treatments with Aminoguanidine and Methylprednisolone on Neurological Recovery after Spinal Cord Injury
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Lee HH
Yang Jun-Young
Lee June-Kyu
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Abstract
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Purpose: To evaluate the effect of a combined treatment with aminoguanidine (AG) and methylprednisolone
(MP) on the neurological recovery after a spinal cord injury (SCI).
Materials and Methods: SCI models (weight-drop) of Sprague Dawley rat were divided into 4 groups after the SCI. Group I was injected with normal saline, Group II with MP, Group III with AG and Group IV with MP and AG. The behavioral and immunohistochemical changes along with RT-PCR of TNFRI, TNFRII, XIAP, IL-6, and IL-6R were analyzed quantitatively and compared.
Results: At 7 days, motor recovery was observed in groups II, IV, III, and I with the level of improvement increasing in that order. Neuron cells were observed in groups II, IV=III, and I. TNFRI was not expressed in group I, but was expressed at a similar level in groups II, III and IV. TNFRII was expressed the most in group II but was not expressed in group I. The level of XIAP expression was similar to that of TNFRII. Groups II and IV showed almost no IL-6 expression, while groups I and III showed similar levels of expression. IL-6-R showed an opposite pattern to IL-6.
Conclusion: Both drugs have a neuroprotective effect but there was no synergistic effect for simultaneous administration.
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KEYWORD
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Spinal cord injury, Methylprednisolone, Aminoguanidine
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